Yes, it's possible. Take a look at https://www.rfaircloth.com/2017/02/10/building-perfect-syslog-collection-infrastructure/ for examples on how to generate GUIDs for new HEC tokens. You then add the GUID as a new http stanza in inputs.conf with the corresponding indexes it can access.
Here's what your config might look like
[http]
disabled=0
port=8088
dedicatedIoThreads=2
maxThreads = 0
maxSockets = 0
useDeploymentServer=0
[http://security]
disabled = 0
index = syslog
indexes = wineventlog,cisco,antivirus
sourcetype = syslog
token = 49775a02-74d0-43e1-845f-d57d0558bd45
useACK = 0
[http://applications]
disabled = 0
index = syslog
indexes = apache,myapp,etc
sourcetype = syslog
token = 0880377a-3d06-4da5-a36c-cea9e2022d40
useACK = 0
... View more